COVID-19 alert: Travel requirements are changing rapidly, including need for pre-travel COVID-19 testing and quarantine on arrival.

Cheap Holidays to Cayo Guillermo

Choose two or more items and save on your trip:

Your next trip to Cayo Guillermo with ebookers

  • Browse our 2021 holiday package deals today! They feature hotels and flights or cars at discounted bundled rates. Book your perfect trip all in one place!
  • You're in luck! We have amazing deals on wonderful properties in Cayo Guillermo. Start browsing our accommodations simply by using the wizard above.
  • We offer free cancellation on most hotels in case you need to change your plans*

For more information, visit our COVID-19 information page
Find the trip that is just right for you now!

*Some hotels require you to cancel at least 24-48 hours before check-in. Details on site.

Top deals for trips to Cayo Guillermo

Chelsea Savoy Hotel
Nyma The New York Manhattan Hotel
Amsterdam Court Hotel
TBA Times Square
City Club Hotel

Cayo Guillermo Holiday Packages for 3 Nights

Villa Agrippina Gran Meliá - The Leading Hotels of the World
Baglioni Hotel Regina - The Leading Hotels of the World
Margutta 19 - Small Luxury Hotels of the World

Cayo Guillermo Holiday Packages for 4 Nights

Chelsea Savoy Hotel
DoubleTree by Hilton Metropolitan - New York City
Row NYC
Millennium Hotel Broadway Times Square
The Hotel @ Fifth Avenue

Cayo Guillermo Holiday Packages for 5 Nights

Villa Agrippina Gran Meliá - The Leading Hotels of the World
OYO Hotel and Casino Las Vegas
Stendhal Luxury Suites
Eastside Cannery Casino & Hotel
The H'All Tailor Suite Roma

Cayo Guillermo Holiday Packages for 6-7 Nights

The Palazzo at The Venetian
Villa Agrippina Gran Meliá - The Leading Hotels of the World
The Venetian Resort Las Vegas
Four Seasons Los Angeles at Beverly Hills

^Savings based on all package bookings with Flight + Hotel made on ebookers.com from as compared to the price of the same components booked separately. Savings will vary based on origin/destination, length of trip, stay dates and selected travel supplier(s). Savings not available on all packages.